| Primary Identifier | MGI:87889 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 110835 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable acetylcholine binding activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within response to nicotine. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is expressed in several structures, including brain; gut; lung; trigeminal nerve; and vagus ganglion. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cocaine abuse; esophagus squamous cell carcinoma; nicotine dependence; and respiratory system cancer (multiple). Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). PHENOTYPE: Mice homozygous for a knock-out allele are less sensitive to nicotine-induced seizures and exhibit a significantly shorter latency time to seizure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
