| Primary Identifier | MGI:1920024 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 72774 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA N-glycosylase activity and lyase activity. Acts upstream of or within DNA repair. Located in nucleus. Is expressed in ductus deferens; embryo; epididymis; and metanephros. Used to study abdominal obesity-metabolic syndrome and obesity. Orthologous to human NEIL1 (nei like DNA glycosylase 1). PHENOTYPE: Homozygous null mice develop severe obesity, dyslipidemia, fatty liver disease and tend to show hyperinsulinemia and increased mtDNA damage and deletions. Sporadic phenotypes include reduced subcutaneous fat, skin ulcers, joint inflammation, infertility,and tumors. Male heterozygotes become obese. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
