| Primary Identifier | MGI:104662 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 18854 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables SMAD binding activity. Involved in several processes, including defense response to symbiont; regulation of macromolecule metabolic process; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and cellular response to cytokine stimulus. Located in PML body; cytosol; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). PHENOTYPE: Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
