| Primary Identifier | MGI:108077 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 20320 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cell-cell adhesion mediator activity; transmembrane transporter binding activity; and type 1 fibroblast growth factor receptor binding activity. Involved in intracellular calcium ion homeostasis and negative regulation of cytokine production. Acts upstream of or within excitatory synapse assembly; modulation of chemical synaptic transmission; and regulation of receptor localization to synapse. Located in immunological synapse. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human NPTN (neuroplastin). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal dendritic spine morphology, decreased CNS synapse formation, abnormal CNS synaptic transmission and impaired hearing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
