Primary Identifier | MGI:1920923 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 73673 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in meiotic DNA double-strand break formation; oogenesis; and spermatogenesis. Located in chromosome. Is expressed in inner cell mass; ovary; primary oocyte; and secondary oocyte. Orthologous to human REC114 (REC114 meiotic recombination protein). PHENOTYPE: Homozygous inactivation of this gene results in meiotic defects including failure of double strand break formation and homologous synapsis, severe defects in spermatogenesis and oogenesis, and both male and female sterility. [provided by MGI curators] |