Primary Identifier | MGI:1913962 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 66712 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in sperm-egg recognition. Acts upstream of or within acrosome reaction and fusion of sperm to egg plasma membrane involved in single fertilization. Located in acrosomal vesicle. Orthologous to human SPESP1 (sperm equatorial segment protein 1). PHENOTYPE: Heterozygous and homozygous null mutant males show decreased fertilization frequency and delayed fertilization, otherwise homozygous null mice were healthy and showed no overt developmental abnormalities. [provided by MGI curators] |