Primary Identifier | MGI:2444710 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 235472 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within negative regulation of neurogenesis. Located in plasma membrane. Is expressed in several structures, including embryo ectoderm; eye; mandible primordium; primitive streak; and somite. Orthologous to human PRTG (protogenin). PHENOTYPE: Homozygous null mice show partial lethality within 72 hours of birth due to malnutrition from defective craniofacial structures including palatal bones and nasal septum. Further lethality is seen before P14, with mice showing growth retardation. [provided by MGI curators] |