Primary Identifier | MGI:2149021 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 208898 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Involved in negative regulation of synaptic plasticity and synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission. Is active in calyx of Held and parallel fiber to Purkinje cell synapse. Is expressed in several structures, including brain; limb interdigital region; molar; olfactory epithelium; and spinal cord mantle layer. Orthologous to human UNC13C (unc-13 homolog C). PHENOTYPE: Homozygous mutant mice demonstrate an impaired ability to learn complex motor tasks, putatively due to an observed increase in paired-pulse facilitation. [provided by MGI curators] |