| Primary Identifier | MGI:2680765 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 387285 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). PHENOTYPE: Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-likebehavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
