Primary Identifier | MGI:108045 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 14531 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including extraembryonic component; limb; metanephros; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired branching of the chorioallantoic interface, absence of the placental labyrinth, lack of fusion of chorionic trophoblast cells, and lethality between embryonic days 5.5-10. [provided by MGI curators] |