Primary Identifier | MGI:1917848 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 70598 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in modification of postsynaptic structure. Acts upstream of or within cerebral cortex development; corpus callosum development; and neuron migration. Is active in glutamatergic synapse. Is expressed in adrenal gland; bladder wall; embryo; head; and piriform cortex. Orthologous to human FILIP1 (filamin A interacting protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit altered positioning of cortical neurons and altered localization of the callosal projection neurons, decreased dendritic spine length of piriform cortex pyramidal neurons, and impaired propagation of excitation in the visual cortex. [provided by MGI curators] |