| Primary Identifier | MGI:105380 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 17216 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA replication origin binding activity; enzyme binding activity; and histone binding activity. Acts upstream of or within DNA unwinding involved in DNA replication; cellular response to interleukin-4; and nucleosome assembly. Located in nucleus. Part of MCM complex and nuclear origin of replication recognition complex. Is expressed in several structures, including central nervous system; future brain; inner cell mass; limb; and tooth. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). PHENOTYPE: Mice homozygous for non functional alleles at this locus die prematurely. There is an increased tumor incidence and abnormalities in a variety of systems in mice as they become moribund. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
