| Primary Identifier | MGI:1349428 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 26927 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; eye; pituitary gland; and reproductive system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). PHENOTYPE: Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
