| Primary Identifier | MGI:1922019 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 74769 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 1-phosphatidylinositol-3-kinase activity and insulin receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of intracellular signal transduction; and response to ischemia. Acts upstream of or within several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). PHENOTYPE: Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5 [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
