| Primary Identifier | MGI:101766 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 20187 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Wnt receptor activity; Wnt-protein binding activity; and frizzled binding activity. Involved in Wnt signaling pathway and nervous system development. Acts upstream of or within several processes, including commissural neuron axon guidance; negative chemotaxis; and negative regulation of axon extension involved in axon guidance. Located in cytoplasm; nucleus; and plasma membrane. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RYK (receptor like tyrosine kinase). PHENOTYPE: Homozygous null mice have a distinctive craniofacial appearance, shortened limbs and postnatal mortality due to feeding and respiratory complications associated with a complete cleft of the secondary palate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
