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Protein Coding Gene : Cish cytokine inducible SH2-containing protein
Primary Identifier  MGI:103159 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  12700
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable cytokine receptor binding activity. Acts upstream of or within negative regulation of cytokine-mediated signaling pathway. Located in plasma membrane. Is expressed in heart; liver; retina; and thymus primordium. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanced Th2 and Th9 differentiation and allergic airway inflammation. [provided by MGI curators]
  • synonyms:
  • CIS1,
  • MGI:2143029,
  • cytokine inducible SH2-containing protein,
  • AI385595,
  • Cish,
  • Cis,
  • expressed sequence AI385595,
  • MGD-MRK-24025,
  • cytokine-inducible SH2 protein,
  • F23
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