| Primary Identifier | MGI:2443101 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 226025 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables G-protein beta/gamma-subunit complex binding activity; monoatomic ion transmembrane transporter activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in metal ion transport and protein homotetramerization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in cochlea; liver; nervous system; and retina. Used to study cataract and microphthalmia. Human ortholog(s) of this gene implicated in cataract. Orthologous to human TRPM3 (transient receptor potential cation channel subfamily M member 3). PHENOTYPE: Homozygous knockout leads to impaired thermal and chemical nociception. Homozygous KO also results in small eyes and lenses, while a specific point mutation additionally leads to cataracts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
