| Primary Identifier | MGI:2685973 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 636931 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables miRNA binding activity and ubiquitin protein ligase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; miRNA-mediated gene silencing by inhibition of translation; and protein autoubiquitination. Acts upstream of or within neural tube closure; positive regulation of miRNA-mediated gene silencing; and regulation of protein metabolic process. Located in P-body. Is expressed in several structures, including branchial arch; extraembryonic component; limb bud; nervous system; and reproductive system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). PHENOTYPE: Homozygous gene trap mutations of this gene result in failure of cranial neural tube closure and embryonic lethality. Homozygotes for a gene trap allele exhibit exencephaly, abnormal nasal process and facial prominence, reduced brain size, and embryonic or fetal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
