| Primary Identifier | MGI:1345149 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 24046 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables voltage-gated sodium channel activity. Involved in several processes, including behavioral response to chemical pain; detection of stimulus involved in sensory perception of pain; and monoatomic cation transmembrane transport. Acts upstream of or within establishment of localization in cell and sodium ion transport. Located in C-fiber and plasma membrane. Is active in axonal growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and sensory organ. Used to study familial episodic pain syndrome 3 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). PHENOTYPE: Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
