| Primary Identifier | MGI:1913923 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 66673 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable transmembrane signaling receptor activity. Involved in positive regulation of synaptic transmission; postsynaptic modulation of chemical synaptic transmission; and regulation of synaptic plasticity. Acts upstream of or within learning; memory; and regulation of long-term synaptic depression. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; cochlea; genitourinary system; retina; and trigeminal ganglion. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit absent NMDA and glutamate receptor-dependent long term depression, impaired spatial learning and memory and impaired fear memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
