Primary Identifier | MGI:1913696 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 66446 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including brain; genitourinary system; gut; submandibular gland primordium; and tooth. Orthologous to human EXOSC7 (exosome component 7). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture. [provided by MGI curators] |