| Primary Identifier | MGI:1859615 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 54644 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5). PHENOTYPE: Male chimeras hemizygous for a gene trapped allele exhibit abnormalities in developmental patterning and embryo turning. Mice homozygous for a conditional allele activated in T cells exhibit increased Th17 differentiation and susceptibility to injection with anti-CD3 antibodies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
