| Primary Identifier | MGI:1298407 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 21912 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in membrane and postsynapse. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; gut; peripheral nervous system ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered hippocampal neurons, reduced mEPSC amplitudes and frequencies, reduced long term potentiation, reduced recognition of novel objects, impaired spatial working memory and spatial learning, and impaired associative memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
