| Primary Identifier | MGI:103064 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 13205 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly and stress granule assembly. Acts upstream of or within with a negative effect on primary miRNA processing. Located in cytoplasmic stress granule. Part of NLRP3 inflammasome complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). PHENOTYPE: Hemizygous males and heterozygous females with a maternally inherited null allele show early embryonic and fetal lethality, respectively. Both males and females show defects in trophoblast giant cells. Females show defects in placental formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
