| Primary Identifier | MGI:1915384 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 68134 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA binding activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of mRNA cis splicing, via spliceosome. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay). PHENOTYPE: Mice homozygous or hemizygous for a null mutation display impaired startle responses, prepulse inhibition, and cued and contextual fear conditioning behavior, limb grasping, decreased neuronal precursor proliferation, and increased neuronal precursor proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
