Primary Identifier | MGI:1933247 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 83563 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). PHENOTYPE: Male mice hemizygous for a null allele exhibit normal fecundity. Mice homozygous for a different allele exhibit male subfertility. [provided by MGI curators] |