Primary Identifier | MGI:2387107 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 75590 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human DUSP9 (dual specificity phosphatase 9). PHENOTYPE: Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice. [provided by MGI curators] |