| Primary Identifier | MGI:2684360 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 723814 |
| Mgi Type | miRNA gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Is expressed in cerebral cortex intermediate zone; cortical plate; embryo; liver; and lung. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human MIR223 (microRNA 223). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hypermature granulocytes that are hypersensitive to activating stimuli and display increased fungicidal activity. Mutant mice develop inflammatory lung pathology and show exaggerated tissue destruction afterendotoxin challenge. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
