| Primary Identifier | MGI:2444609 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 245537 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including cell adhesion molecule binding activity; neurexin family protein binding activity; and scaffold protein binding activity. Involved in several processes, including chemical postsynaptic transmission; modulation of chemical synaptic transmission; and regulation of synapse organization. Acts upstream of or within several processes, including oligodendrocyte differentiation; regulation of respiratory gaseous exchange by nervous system process; and visual learning. Predicted to be located in several cellular components, including excitatory synapse; inhibitory synapse; and postsynaptic membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; eye; and heart. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN3 (neuroligin 3). PHENOTYPE: Homozygous null mice show impaired context and cued conditioning, hyperactivity, altered social behavior, less vocalization, smaller brains, and impaired olfaction. Males carrying a knock-in allele show impaired social interaction, and enhanced spatial learning and inhibitory synaptic transmission. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
