| Primary Identifier | MGI:1855692 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 53610 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chromatin binding activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; central nervous system ganglion; gut; sensory organ; and testis. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). PHENOTYPE: Mice carrying a gene trap trap allele show shortening of the circadian period under constant dark conditions. Chimeras for some other gene trap alleles may display gastrulation defects. Hemizygous KO in males causes cardiac fibrosis and results in decreased body weight and increased mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
