Primary Identifier | MGI:108023 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 12705 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of macromolecule biosynthetic process; and response to type II interferon. Acts upstream of or within labyrinthine layer development; spongiotrophoblast layer development; and vasculogenesis. Located in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and heart. Orthologous to human CITED1 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1). PHENOTYPE: Mutation of this locus results in impaired embyronic growth and survival due to defects in trophoblast and placental development. Phenotypic penetrance is subject to influence by genetic background and parental inheritance. [provided by MGI curators] |