Primary Identifier | MGI:1336196 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 22097 |
Mgi Type | antisense lncRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within inactivation of paternal X chromosome by genomic imprinting; negative regulation of transcription by RNA polymerase II; and transcription initiation-coupled chromatin remodeling. Is expressed in several structures, including early conceptus; liver; and retina nuclear layer. Orthologous to human TSIX (TSIX transcript, XIST antisense RNA). PHENOTYPE: Maternal transmission of a null allele in this imprinted gene prevents Xist accumulation disrupting X-inactivation and causing early embryonic lethality. [provided by MGI curators] |