| Primary Identifier | MGI:1351606 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 27359 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables neurexin family protein binding activity and phospholipid binding activity. Acts upstream of or within exocytosis and negative regulation of insulin secretion. Located in plasma membrane and secretory granule. Is expressed in diencephalon lateral wall ventricular layer; endocrine gland; foregut-midgut junction; and paravertebral ganglion. Orthologous to human SYTL4 (synaptotagmin like 4). PHENOTYPE: Targeted inactivation of this gene leads to reduced body weight, enhanced glucose tolerance, defective granule docking at the plasma membrane in pancreatic beta cells and corticotrophs, and a significant increase in evoked insulin and adrenocorticotropinsecretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
