| Primary Identifier | MGI:1913490 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 66240 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including cardiac muscle cell action potential involved in contraction; regulation of cardiac muscle cell membrane repolarization; and regulation of potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including embryo mesenchyme; ganglia; gonad; skeletal musculature; and ventricular layer. Orthologous to human KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5). PHENOTYPE: Males hemizygous for null alleles show ventricular arrhythmia (ventricular premature beat), increased susceptibility to induction of polymorphic ventricular tachycardia, shorter ventricular refractory period, and augmented ventricular potassium currents. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
