| Primary Identifier | MGI:1339656 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 18481 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis; dendritic spine morphogenesis; and regulation of postsynapse organization. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; gonad; liver; retina; and sciatic nerve. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). PHENOTYPE: Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
