| Primary Identifier | MGI:1277954 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 16165 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within immunoglobulin mediated immune response; negative regulation of immunoglobulin production; and negative regulation of mast cell degranulation. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; liver; lung; smooth muscle tissue; and spleen. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2). PHENOTYPE: Null mice display a phenotype consistent with attenuated IL13 responsiveness, including abnormal serum protein concentrations, increased frequency of bone marrow macrophage progenitor cells, and abnormal response of tissue macrophage to LPS. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
