| Primary Identifier | MGI:2448588 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 270672 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15). PHENOTYPE: Male mice hemizygous for a knock-out allele exhibit hyperactivation of the SPAK/OSR1 and Na+Cl- cotransporter (NCC) pathway in the renal tubules and develop mild hypertension. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
