Primary Identifier | MGI:95748 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 237213 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including cellular response to ethanol; cellular response to zinc ion; and chloride transmembrane transport. Predicted to act upstream of or within monoatomic ion transport. Is active in glycinergic synapse. Is expressed in brain; spinal cord; and vascular element. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA2 (glycine receptor alpha 2). PHENOTYPE: Mice homozygous for a null allele lack cortical neuron responses to glycine and taurine but are otherwise normal. Mice homozygous for another targeted allele exhibit impaired interneuron migration into the cortical wall. [provided by MGI curators] |