Primary Identifier | MGI:99510 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 19241 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin monomer binding activity; enzyme binding activity; and protein sequestering activity. Acts upstream of or within regulation of cell migration. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart and pericardium; and tooth. Orthologous to several human genes including TMSB4X (thymosin beta 4 X-linked). PHENOTYPE: Mice homozygous for a knockout allele are viable and fertile with no notable cardiovascular defects in adult mice. Mice homozygous for a different allele exhibit partial embryonic lethality due to vascular defects associated with impaired differentiationof mural cells from mesoderm in some mice. [provided by MGI curators] |