| Primary Identifier | MGI:98731 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 21817 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). PHENOTYPE: A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
