| Primary Identifier | MGI:1347355 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 26570 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable transmembrane transporter activity. Involved in L-cystine transport and lysosomal lumen pH elevation. Acts upstream of or within several processes, including brain development; intracellular glutamate homeostasis; and oligopeptide transmembrane transport. Located in astrocyte projection and brush border membrane. Is expressed in brain; eye; olfactory epithelium; and spinal cord meninges. Used to study Hermansky-Pudlak syndrome and platelet storage pool deficiency. Orthologous to human SLC7A11 (solute carrier family 7 member 11). PHENOTYPE: Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
