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Protein Coding Gene : Arhgef26 Rho guanine nucleotide exchange factor 26
Primary Identifier  MGI:1918053 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  622434
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Predicted to be located in plasma membrane. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering. [provided by MGI curators]
  • synonyms:
  • 8430436L14Rik,
  • MGI:2139660,
  • RIKEN cDNA 8430436L14 gene,
  • MGI:1918810,
  • AI303572,
  • 4631416L12Rik,
  • AW491953,
  • Arhgef26,
  • Rho guanine nucleotide exchange factor 26,
  • RIKEN cDNA 4631416L12 gene,
  • expressed sequence AW491953,
  • MGI:2139988,
  • expressed sequence AI303572
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