| Primary Identifier | MGI:1929895 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 65945 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in neurotransmitter receptor transport to postsynaptic membrane and regulation of synapse maturation. Acts upstream of or within regulation of cell growth. Located in several cellular components, including cell surface; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic endosome. Is expressed in alimentary system; central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human CLSTN1 (calsyntenin 1). PHENOTYPE: Juvenile mice homozygous for a null allele show reduced basal excitatory synaptic transmission, abnormal excitatory postsynaptic currents, enhanced NMDA receptor-dependent long term potentiation, and delayed dendritic spine maturation in CA1 hippocampal pyramidal cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
