| Primary Identifier | MGI:1920722 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 73472 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable cardiolipin binding activity; identical protein binding activity; and molecular condensate scaffold activity. Predicted to be involved in mitochondrial protein catabolic process; mitophagy by internal vacuole formation; and positive regulation of cardiolipin metabolic process. Predicted to act upstream of or within cardiolipin acyl-chain remodeling and cardiolipin biosynthetic process. Predicted to be located in several cellular components, including mitochondrial matrix; nucleoplasm; and sperm flagellum. Predicted to be active in mitochondrial outer membrane. Orthologous to human SPATA18 (spermatogenesis associated 18). PHENOTYPE: Homo- or heterozygous KO in mice also carrying one copy of the ApcMin allele leads to increased intestinal adenoma and adenocarcinoma tumor incidence and size. This double mutation and homozygous KO of the gene alone results in lower internal mitochondrial cristae density in small intestinal mucosal epithelium. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
