| Primary Identifier | MGI:2384034 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 211064 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables broad specificity oxidative DNA demethylase activity and chemoattractant activity. Involved in positive regulation of gene expression, epigenetic and regulation of translational initiation by tRNA modification. Acts upstream of or within several processes, including generation of neurons; in utero embryonic development; and negative regulation of neuron apoptotic process. Located in euchromatin. Is expressed in several structures, including branchial arch; central nervous system; hemolymphoid system gland; hindlimb muscle; and limb bud. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). PHENOTYPE: Mice homozygous for a null allele show delayed fetal growth, impaired placental development and low birth weight. Mice homozygous for another null allele show sex-ratio distortion, reduced survival, spermatogenic defects and incompletely penetrant eye, neural tube, skeleton and craniofacial defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
