| Primary Identifier | MGI:2686979 | Organism | mouse, laboratory |
| Chromosome | 12 | Mgi Type | gene segment |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables antigen binding activity. Acts upstream of or within antibacterial humoral response and humoral immune response mediated by circulating immunoglobulin. Located in extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). PHENOTYPE: Homozygotes for a G400R mutation show reduced tumorigenesis in colon carcinoma models with increased tumor-associated antigen-specific IgG2c antibodies and antibody-dependent tumor cell phagocytosis. Mice with a truncation in the cytoplasmic tail of the membrane-bound Ighg2c heavy chain show increased tumorigenesis in colon carcinoma models. [provided by MGI curators] |
| specificity | Ighg2c (Igh-1b allele) in C57BL/6J and Ighg2a (Igh-1a allele) are distict isotypes located between Ighg2b and Ighe. |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
