| Primary Identifier | MGI:87854 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 11287 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable endopeptidase inhibitor activity and protease binding activity. Located in extracellular matrix. Is expressed in liver and liver lobe. PHENOTYPE: Homozygotes mutant null mice show higher bone mineral density, hypoactivity, and decreased heart rate. Mice homozygous for a different null allele show resistance to the lethal effects of endotoxin, increased susceptibility to diet-induced acute pancreatitis, and altered LPS-induced febrile and cytokine responses. [provided by MGI curators] |