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Protein Coding Gene : Pzp2 PZP alpha-2-macroglobulin like 2

Primary Identifier  MGI:87854 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  11287
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable endopeptidase inhibitor activity and protease binding activity. Located in extracellular matrix. Is expressed in liver and liver lobe.
PHENOTYPE: Homozygotes mutant null mice show higher bone mineral density, hypoactivity, and decreased heart rate. Mice homozygous for a different null allele show resistance to the lethal effects of endotoxin, increased susceptibility to diet-induced acute pancreatitis, and altered LPS-induced febrile and cytokine responses. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-1006,
  • MGI:8227967,
  • Pzp2,
  • MGI:2141514,
  • pregnancy zone protein,
  • Pzp,
  • PZP, alpha-2-macroglobulin like,
  • PZP alpha-2-macroglobulin like 2,
  • expressed sequence AI893533,
  • AI893533

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Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Expression

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Disease

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