| Primary Identifier | MGI:104730 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 11499 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; male gonad development; and proteolysis. Is active in cell surface. Is expressed in central nervous system and sensory organ. Orthologous to human ADAM5 (ADAM metallopeptidase domain 5 (pseudogene)). PHENOTYPE: Mice homozygous for a knock-out allele show severe male subfertility, impaired sperm binding to the zona pellucida and to extracellular matrix components, and impaired uterotubal junction transit, but no alterations in spermatogenesis, sperm morphology or sperm motility. Female fertility is normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
