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Protein Coding Gene : Ncapd3 non-SMC condensin II complex, subunit D3

Primary Identifier  MGI:2142989 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  78658
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable histone binding activity. Involved in cerebral cortex development; mitotic chromosome condensation; and regulation of chromosome segregation. Acts upstream of or within meiotic chromosome separation. Located in condensed nuclear chromosome; germinal vesicle; and kinetochore. Part of condensin complex. Is expressed in cerebral cortex subventricular zone. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 22. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation. [provided by MGI curators]
  • synonyms:
  • MGI:2143198,
  • Ncapd3,
  • 2810487N22Rik,
  • MGI:1925908,
  • expressed sequence AI195468,
  • B130055D15Rik,
  • AI195468,
  • non-SMC condensin II complex, subunit D3,
  • RIKEN cDNA B130055D15 gene,
  • 4632407J06Rik,
  • MGI:1922964,
  • RIKEN cDNA 4632407J06 gene,
  • AU018739,
  • mKIAA0056,
  • RIKEN cDNA 2810487N22 gene,
  • expressed sequence AU018739

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