| Primary Identifier | MGI:1923749 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 76499 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables microtubule binding activity. Involved in establishment of cell polarity. Acts upstream of or within cell migration; establishment or maintenance of cell polarity; and negative regulation of microtubule depolymerization. Located in Golgi apparatus; cell leading edge; and microtubule. Is expressed in several structures, including 1-cell stage conceptus; 2-cell stage conceptus; central nervous system; oocyte; and trigeminal nerve. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
